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KMID : 0615720110280030033
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Jouranl of Korean Acupuncture and Moxibustion society
2011 Volume.28 No. 3 p.33 ~ p.42
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Effects of Scutellariae Radix on Locomotor Dysfunction of Contusive Spinal Cord Injury Induced Rats
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Kim Eun-Seok
Kim Pyung-Soo
Kim Bum-Hoi
Shin Jung-Won
Kim Seong-Joon
Sohn Nak-Won
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Abstract
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Objectives:This study was performed to evaluate the effects of Scutellariae radix (SR) water extract on locomotor dysfunction induced by spinal cord injury (SCI) in rats.
Methods: SCI was induced mechanical contusion following laminectomy of 10 th thoracic vertebra in Sprague-Dawley rats. SR was orally given once a day for 7 days after SCI. Neurological behavior was examined with the Basso-Beattie-Bresnahan locomotor rating scale. Tissue damage and nerve fiber degeneration were examined with cresyl violet and luxol fast blue (LFB) histochemistry. Using immunohistochemistry, cellular damages to neurons and nerve fibers were examined MAP-2.
Results: 1. SR significantly ameliorated the locomotor dysfunction of the SCI-induced rats. 2. SR significantly reduced the number of motor neurons in the ventral horn of the SCI-induced rat spinal cord. 3. SR attenuated the reduction of nerve fiber shirnakage and degeneration of the SCI-induced rat spinal cord. 4. SR attenuated the reduction of MAP-2 positive cells in the peri-lesion of the SCI-induced rat spinal cord.
Conclusions:These results suggest that SR improves the locomotor dysfunction of SCI by reducing degeneration of nerve fibers and motor neuron shrinkage in the ventral horn.
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KEYWORD
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spinal cord injury, locomotor dysfunction, Scutellariae radix, MAP-2
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